Evaluating the tumor subtypes, ANXA1 high expression was specifically associated with an increased mortality in HER2 positive patients (10-years OS: HRadj = 1.60; 95 % CI = 1.06–2.41 and 10-years BCSS: HRadj = 1.70; 95 % CI = 1.17–2.45; Fig. 2b and Additional file 7: Figure S4B). This evidence concerns the gene ERBB2 and neoplasm.