Our previous studies show that subcutaneous and in situ gastric cancer tissues with 5 mm in diameter could be recognized and treated using multifunctional nanoprobes such as BRCAA1(breast cancer associated antigen 1,AF208045) monoclonal antibody-conjugated fluorescent magnetic nanoparticles12, Her2 monoclonal antibody–conjugated RNase-A-associated CdTe quantum dots13, folic acid conjugated upper conversion nanoparticles14, Folate conjugated gold nanorods15, ce6-conjugated carbon dots16, ce6-conjugated Au nanoclusters(Au NCs)17, 18. The gene discussed is ARID4B; the disease is gastric cancer.