Based on these results, we proposed a molecular mechanism of RNA nanoparticle induced MGC803 growth inhibition: the prepared RNA nanoparticles (FA-pRNA-3WJ-BRCAA1 siRNA) actively bind to the folic acid receptor on the surface of MGC803 cells via folic acids conjugated on the RNA nanoparticles, and then induce the endocytosis of RNA nanoparticles into tumor cytoplasm. Here, ARID4B is linked to neoplasm.