IL6 and Duchenne muscular dystrophy: The choice to interfere with Il6 activity at the pre-necrotic stage of the disease in mdx mice was based on this rationale: a) treatment starts before the major initial bout of necrotic damage to mdx muscles occurs, b) analysis and interpretation of data are simplified due to the absence of pre-existing background tissue damage, and c) this young age relates to childhood events in human DMD, therefore making this approach more easily translatable to patients (Grounds et al., 2008).