Changes in cell cycle regulation and cell fate change of neural progenitors were already reported in trisomic mouse models of DS (Haydar and Reeves, 2012) and it was also known that Dyrk1a could somehow influence both cell cycle progression and neurogenesis in vitro and in vivo (Soppa et al., 2014, Yabut et al., 2010). Here, DYRK1A is linked to Dravet syndrome.