Moreover, the expression of IL-13 and the Th2 transcription factor GATA3 by human CD8+ T-cells have been associated with several inflammatory disorders involving tissue fibrosis including atopic dermatitis, psoriasis and sclerosis (Medsger et al., 2011, Hijnen et al., 2013, Fuschiotti et al., 2009, Fuschiotti et al., 2013). This evidence concerns the gene CD8A and atopic eczema.