BCAM and autosomal dominant cerebellar ataxia: Overexpression of Lu/BCAM and ICAM-4 has been demonstrated in SCA (El Nemer et al., 1998, Parsons et al., 1999) and, importantly, functional activation by phosphorylation (Gauthier et al., 2005) results in increased RBC adhesion to vascular endothelium and resistance to high shear-stress forces, thereby contributing to VOC genesis (Kaul et al., 2006).