In this study we expressed and purified the coat protein VP1 from RV16, 89 (RV-A), 14 (RV-B) and C (RV-C) as well as the major epitope-containing N-terminal portions of the VP1 proteins to compare the kinetics, specificities and magnitudes of antibody responses in individuals with and without asthma after experimental RV16 infection. The gene discussed is GOLPH3; the disease is asthma.