B*27/57neg and B*27/57pos LTNP/EC had similar, profound control over HIV (median HIV RNA levels < 50 copies/mL in both groups; p > 0.5) for similarly long durations of infection (medians, 17 versus 24 years, respectively; p > 0.5) and had comparable CD4+ T-cell counts (medians, 913 versus 753 cells/mm3, respectively; p > 0.5). The gene discussed is CD4; the disease is infection.