Significant mutated genes were reported in MM including KRAS (23%), NRAS (20%), FAM46C (11%), TP53 (8%), DIS3 (11%), BRAF (6%), TRAF3 (5%) and PRDM1 (5%) (Chapman et al., 2011, Lohr et al., 2014). This evidence concerns the gene NRAS and Miyoshi myopathy.