TNF and type 2 diabetes mellitus: In T2DM, mRNA expression of CRP, IL-6, NF-κB and TNF-α was decreased by 24.9% (p = 0.046), 15.1% (p = 0.06), 17.7% (p = 0.011) and 33.5% (p = 0.025), respectively (Fig. 4D).