AGT and endothelial dysfunction: Recently, it has been shown that heat treatment in high fat-fed mice augmented angiotensin (Shichiri et al., 2000, Alberti et al., 2005, Ohman et al., 2009, Tamakoshi et al., 2003, Morino et al., 2008a, Adachi et al., 2010, Chung et al., 2008), which counteracts against angiotensin II, through Mas receptor/eNOS axis that may improve blood pressure and endothelial dysfunction (Karpe and Tikoo, 2014).