BCL2 and neoplasm: Paclitaxel, which mediates its cytotoxic action via NF-κB pathway, is vulnerable to develop resistance in the presence of hypoxic tumour microenvironment, with activation of NF-κB transcription factor, which induces serine phosphorylation and also regulates BCL-2, an antiapoptotic protein, preventing cell death and promoting tumorigenesis [76].