INS and Hypoglycemia: Moreover, an identical mutation in AKT2 was found to cause its membrane localization and the insulin-independent membrane localization of the GLUT4 glucose transporter and subsequent hypoglycemia [39]. AKT1 gene variations, including haplotypic variations, have been reported to be associated with various cellular pathological and biological phenotypes, such as resistance to apoptosis in Epstein-Barr virus-transformed lymphocyte cells [40], and the cellular response to DNA damage [40].