MEN1 and adenoma: The majority of adenomas arising in hereditary syndromes are GH-secreting adenomas and they are associated to MEN-1 (linked to somatic mutations of the tumor-suppressor gene MEN-1), Carney’s complex (CNC) (linked to mutations of the tumor-suppressor gene PRKAR1A), and McCune–Albright syndrome (linked to activating mutations of the gsp oncogene).