Hormone-producing PAs release active hormones in excessive amounts into the bloodstream and they are currently classified into five main immunohistochemistry (IHC) types: prolactinoma (PRL, 25–41%) somatotroph adenomas (GH, 10–15%), corticotroph adenomas (ACTH, about 10%), thyrotroph adenomas (TSH, <1%), and gonadotroph adenomas (FSH-LH <1%), which can be monohormonal or plurihormonal, with or without signs of hypersecretion (3). The gene discussed is BRD2; the disease is growth hormone-secreting pituitary adenoma.