Accordingly, the analysis of a miRNA expression profile of GH adenomas versus normal pituitary has unveiled a set of miRNAs constantly deregulated in somatotroph tumors, comprising miR-326, miR-432, and miR-570, targeting HMGA2, miR-34b, and miR-548c-3p both having HMGA1 and HMGA2 as targets, and miR-326 and miR-603 targeting E2F1. The gene discussed is HMGA2; the disease is growth hormone-producing pituitary gland neoplasm.