In support of this, several early-phase clinical trials are currently underway for combined PI3K and BRAF/MEK inhibitors in melanoma, while preclinical melanoma models have reported synergistic growth inhibition and overcoming of acquired or intrinsic resistance to BRAF or MEK inhibitors with PI3K pathway inhibitors (19, 24, 32–35). This evidence concerns the gene MAP2K7 and melanoma.