ADIPOQ and metabolic syndrome: Considering the adiponectin functional role in the metabolic processes of various clinical contexts, and its possibility to become a therapeutic target (Caselli, 2014, Hand et al., 2015), our work aims to contribute to knowledge in the area by evaluating the variant 276G > T (rs1501299) effect on adiponectin levels, and on biochemical markers associated with metabolic syndrome and cardiovascular risk in a population sample from Southern Brazil.