The association of this SNP with adiponectin levels have been established through Genome-Wide Association Studies (GWAs) (Heid et al., 2006a, Heid et al., 2006b, Heid et al., 2010, Pollin et al., 2005), and the association with traits related to metabolic syndrome, diabetes and atherogenic indicators shows heterogeneous results (Al-Daghri et al., 2012, Arikoglu et al., 2014, Kawai et al., 2013, Melistas et al., 2009, Pyrzak et al., 2013, Zhao and Zhao, 2011), probably due to multiple factors that influence its modulation, in addition to methodological differences between studies. This evidence concerns the gene ADIPOQ and metabolic syndrome.