Despite the lack of clarity in the pathogenesis of RA-ILD, several predisposing risk factors have been implicated in the possible development of ILD including male gender, smoking, older age, high RA disease activity, long duration of disease, genetic carriers of HLA-DRB1 ∗1502, HLA-B40, anti-trypsin, anti-CCP, and RF; however other studies reveal conflicting data on these associations [10–14]. This evidence concerns the gene HLA-DRB1 and interstitial lung disease.