Despite the lack of clarity in the pathogenesis of RA-ILD, several predisposing risk factors have been implicated in the possible development of ILD including male gender, smoking, older age, high RA disease activity, long duration of disease, genetic carriers of HLA-DRB1 ∗1502, HLA-B40, anti-trypsin, anti-CCP, and RF; however other studies reveal conflicting data on these associations [10–14]. The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.