One 22q11.2DS gene provides an example of the utility of using the worm system to study 22q11.2DS is DGCR8, a component of the “microprocessor” complex essential for genome-wide miRNA production [91] that may mediate the expression of multiple 22q11.2DS associated phenotypes in patients, including schizophrenia [41–43]. Here, DGCR8 is linked to schizophrenia.