Lower cerebrospinal fluid (CSF) levels of the 42–amino acid–long Aβ peptide Aβ1–42, reflecting the plaque pathology, together with increased concentrations of total tau (t-tau) and p-tau, reflecting neurodegeneration and tangle pathology, respectively, are today considered the core CSF biomarkers for AD [3]. This evidence concerns the gene MAPT and Alzheimer disease.