ALB and Sepsis: In the randomized, double-blind SAFE study, it was observed that, in the ICU, general fluid replacement with 4% albumin solution compared with 0.9% NaCl solution was safer [7–9]; in the predefined subgroup of patients with severe sepsis, the mortality rate in the albumin group was lower than in the group receiving saline solution (risk of mortality reduced by 29%, p < 0.05), and it was found that particularly those derived greater benefit whose serum albumin levels had been increased to above 25 mg/dL.