SOX2OT and SOX2 co-upregulation has been reported in lung tumor tissues, particularly in squamous cell lung carcinoma (Hussenet et al., 2010; Hou et al., 2014), which is related to 3q26.33 genomic amplification (Hou et al., 2014). The gene discussed is SOX2-OT; the disease is squamous cell lung carcinoma.