Furthermore, SOX2OT exerts regulatory function in cell cycle progression; hence its association with carcinogenesis of human tumors of breast (Askarian-Amiri et al., 2014), esophagus (Shahryari et al., 2014), and lung (Hussenet et al., 2010; Hou et al., 2014) cancers is not surprising. The gene discussed is SOX2-OT; the disease is cancer.