C19orf12 was predicted to contains two α-helices located in the trans-membrane (TM) region (Supplementary Figure 3) rich in glycine residues, of which several have been found mutated in MPAN patients: G58S (Panteghini et al., 2012), G53R, G65E, G69R, (Landouré et al., 2013) C19orf12 contains in the transmembrane helix glycine zipper motifs, (GxxxGxxxG) (Kruer et al., 2014). The gene discussed is C19orf12; the disease is neurodegeneration with brain iron accumulation 4.