Some studies have detected higher numbers of IFN-γ-secreting cells (192, 193), higher numbers of T cells reactive with DRB1*0401/MOG97–109-tetramer (194), higher proliferative responses of peripheral blood lymphocytes (PBL) (195), or higher proliferative responses of T cells to certain MOG epitopes (196) in MS patients than in healthy controls. The gene discussed is IFNG; the disease is myeloid sarcoma.