MAPT and Alzheimer disease: Based on the DeLong tests (Table 6), the Aβ1–42/P-tau181P ratio performed significantly better than Aβ1–42 and T-tau to discriminate AD from FTD, while the AUC of P-tau181P/T-tau was significantly better than those of Aβ1–42, T-tau, and Aβ1–42/P-tau181P to differentiate between AD and CJD.