RUNX2 and autism: Even more so is the fact that both Runx2 and Foxp2 are found among Auts2 regulatory targets (Oksenberg et al., 2014), as is Cntnap2. CNTNAP2 is a well-known FOXP2 target (Vernes et al., 2008) and a candidate for language delay and language impairment (Petrin et al., 2010; Sehested et al., 2010), intellectual disability (Gregor et al., 2011), and autism (Alarcón et al., 2008; Bakkaloglu et al., 2008), The AMH CNTNAP2 exhibits a fixed change (Ile345Val) compared to the Denisovan protein (Meyer et al., 2012).