Two human tumor xenograft models with known KRAS and PIK3CA mutations (CUCRC40 and CUCRC98) were treated with alisertib and trametinib as single agents and in combination at various doses: alisertib 10 and 20 mg/kg and trametinib 0.5 and 1.5 mg/kg. Here, PIK3CA is linked to neoplasm.