A more pronounced synergistic effect was observed in the KRAS/PIK3CA MT (double-mutant) CRC cell lines, with a mean CI value of 0.55 ± 0.05, as compared to 53.68 ± 5.48 in the KRAS MT/PIK3CA WT model, 0.89 ± 0.097 in the KRAS WT/PIK3CA WT model, and 0.876 ± 0.077 in the BRAF MT model (Figure 1A). Here, PIK3CA is linked to colorectal carcinoma.