INS and type 1 diabetes mellitus: Interestingly, LRP1 expression is downregulated in brain capillaries of streptozotocin-injected mice (Hong et al., 2009) and CSF soluble LRP1 is increased in type 1 diabetes patients treated with insulin for several years (Ouwens et al., 2014), suggesting that insulin might increase central LRP1, at least on the long term.