Similar to other neurodegenerative diseases, Alzheimer’s disease (AD) is a proteinopathy, in which accumulation of insoluble aggregates of Amyloid-β (Aβ), tau and TDP-43 occurs (Tremblay et al., 2007, 2011; Serrano-Pozo et al., 2011). Here, TARDBP is linked to Alzheimer disease.