CBARP and Anxiety: In this study, we found that BARP KO mice have hypo-locomotor activity as evidenced by decreased vertical activity, stereotypic counts in the open field test, and activity level in the home cage, and longer latency to complete a session in spontaneous T-maze alteration test, which reached “study-wide significance.” In addition, some suggestive evidence showed that BARP KO mice may have increased anxiety-like behavior and multiple behavioral phenotypes that are seemingly opposite to those seen in the mouse models of schizophrenia and its related disorders.