Altered acetylation of both nuclear and cytoplasmic non-histone proteins has also been associated with AD, including NF-κB (Chen et al., 2001), p53 (Barlev et al., 2001), alpha tubulin (Perez et al., 2009), and tau (Min et al., 2010; Irwin et al., 2012), adding another level of regulation to molecular pathways in AD. This evidence concerns the gene H2BC12L and Alzheimer disease.