In light of the evidence that bicarbonate transporters of the SLC4A family including SLC4A10 are involved in seizure disorders (Gurnett et al., 2008; Krepischi et al., 2010; Belengeanu et al., 2014), a better understanding of their role for synaptic transmission is desirable to get a more comprehensive view of neuronal excitability and the pathophysiology of epilepsy (Chesler, 2003; Leniger et al., 2004). Here, SLC4A10 is linked to epilepsy.