SORL1 and Alzheimer disease: Significantly, there have been reports of decreased SorLA levels in late-onset AD patients (Scherzer et al., 2004) and polymorphisms in the SorLA gene are linked to both early and late-onset AD patients (Rogaeva et al., 2007; Grear et al., 2009; Caglayan et al., 2012; Pottier et al., 2012).