Furthermore, genetically enforced overexpression of amylin in rodents transgenic for the human form of amylin leads to amylin oligomerization and amyloid formation in pancreatic β-cells, β-cell apoptosis, and eventual development of T2DM (Matveyenko and Butler, 2006; Huang et al., 2007). Here, IAPP is linked to type 2 diabetes mellitus.