IAPP and type 2 diabetes mellitus: In T2DM, the precise relationship between altered peripheral amylin production and central amylin amyloid formation appears complex and may be critically dependent on the temporal course of progressive pancreatic β-cell dysfunctions: Hyperamylinemic conditions may be more relevant for the early processes of amyloid formation in the CNS, whereas hypoamylinemic conditions may be more strongly associated with late stages of central amyloid pathologies.