↑ active JNK and IRS-1pSer616 levelsRedistribution of IRS-1pSer616 expression from nucleus to cytosol in AD human patients and 3×Tg-AD↑ IRS-1pSer616 colocalized with NFTsAβ oligomer induced expression of IRS-1pSer616 in hippocampal neurons culture. This evidence concerns the gene MAPK8 and Alzheimer disease.