HIF-1α and its regulators (HDAC-1, HDAC-7, VHL-E3, PHD2, LL-37, HIF-1β, mTOR, miR-210, RORγt, STAT3, and IL-13Ralpha, as well as glycolysis enzymes) could be important pharmacological targets to restore the lack of regulation in the angiogenesis and in immunological processes involved in psoriasis. The gene discussed is STAT3; the disease is psoriasis.