As previously described, HIF-1α is a transcription factor that acts over several target genes, but HIF-1α plays an important role in the expression of proangiogenic genes implicated in psoriasis, such as “vascular endothelial growth factor” (VEGF) [80–83], VEGF receptors FLT-1 [83] and FLK-1 [84], “plasminogen activator inhibitor-1” (PAI-1) [85], angiopoietins [86], TIE-2 [86], “matrix metalloproteinases” MMP-2 and -9 [87] calcitonin receptor-like receptor, Sema4D [71, 72], and “cytokine stem cell factor” (SCF) [88]. Here, SERPINE1 is linked to psoriasis.