In this point, it is important to remember that transgenic mice to STAT3 and the knockout mice to the “suppressor of STAT3” (SOCS3) developed squamous skin that resembles human psoriasis, and possibly the high expression of STAT3 favored the Th17 differentiation but at the time the assays were not performed [20, 21]. This evidence concerns the gene SOCS3 and psoriasis.