Both Sun and colleagues (Figure 5A) and the TCGA database (data not shown) show statistically significant increases in expression of p47phox (2.58-fold, p < 0.001), Egr-1 (1.43-fold, p < 0.01), and Fyn (1.8-fold, p < 0.001) mRNA, particularly in GBM where EGFR is also amplified. The gene discussed is FYN; the disease is glioblastoma.