In this study, we demonstrate high levels of cytoplasmic hnRNP K in tissue samples of malignant melanoma (MM) and MM metastases compared to benign nevi; moreover, we show for the first time that presence of hnRNP K is essential for DNA damage repair upon IR in NRAS-mutant MM cells. The gene discussed is HNRNPK; the disease is Miyoshi myopathy.