HNRNPK and hepatocellular carcinoma: Taken together, the high baseline radioresistance of melanocytic malignancies might be a consequence of the observed high cytoplasmic hnRNP K levels in these lesions, possibly due to hnRNP K-mediated inhibition of caspase activity as has been previously reported for hepatocellular carcinoma cells under treatment with 5-fluorouracil (5-FU) [34].