NEFL and early-onset autosomal dominant Alzheimer disease: As this is the first study measuring both s- and CSF-NF-L in CNS trauma, we can only compare to a R2 value measured in other neurological diseases (Alzheimer’s disease, Guillain-Barre syndrome and amyotrophic lateral sclerosis) which showed a stronger correlation (R2 = 0.46) [24].