MYC and acute lymphoblastic leukemia: For example, elevated Myc expression is observed in most cases of T cell acute lymphoblastic leukaemia (T-ALL), either as a consequence of a chromosomal translocation event (t(8;14)(q24;q11)) that places Myc under the control of the TCR alpha chain promoter (Erikson et al, 1986; Charrin, 1996) or more commonly as a consequence of Notch mutations that lead to transcriptional activation of Myc (Weng et al, 2004, 2006; Palomero et al, 2006).