MYC and Burkitt lymphoma: For example, stabilisation of Myc protein by a T58A mutation has been described in Burkitt’s lymphoma (Yano et al, 1993; Gregory & Hann, 2000) and inactivating mutations of the E3 ubiquitin ligase Fbw7 that target Myc for proteasomal degradation are frequently found in T-ALL (Welcker et al, 2004a; O’Neil et al, 2007).