PRNP and prion disease: Collectively, the patterns of cellular and sub-cellular localization of PrP-d in i.p. rec-Prion challenged mice in the CNS, LRS and in the enteric nervous system (ENS) are indistinguishable from classical forms of experimental rodent prion disease and of naturally occurring contagious TSEs [46], confirming the diagnosis of rec-Prion caused disease as a TSE or prion disease.