ERBB2 and cancer: For example, HOTAIR functions as a ‘CeRNA' to regulate HER2 expression by sponging miR-331-3p to promote proliferation in gastric cancer.22, 41, 42 Approximately, 20% of the lncRNAs can recruit the PcG complexes to regulate gene expression.43 EZH2 could epigenetically silence the downstream gene transcription, and it is overexpressed in several types of cancer, including gastric cancer.44, 45, 46 In this study, we demonstrated that HOTAIR recruits and binds to PRC2 to epigenetically silence miR34a expression to promote gastric cancer cell-EMT process and metastasis.