Consistent with the CJD-like transmission properties of CJD-102L prions in transgenic mice expressing wild type human PrP, PrPSc typing of the recipient mouse brain showed that the di-glycosylated dominant PrPSc glycoform ratio of CJD-102L prions in the inoculum had switched to a mono-glycosylated PrPSc dominant pattern which more closely resemble CJD prions (Table 3; Fig 2B, 2D and 2F, lanes 5). This evidence concerns the gene PRNP and Creutzfeldt Jacob disease.