The PrPSc type now appeared to more closely resemble the original classical CJD inoculum with a predominance of mono-glycosylated PrP and was readily distinguishable from the di-glycoslyated PrP dominant glycoform pattern seen after secondary passage of GSS 102L prions in 102LL Tg27 mice (Fig 2A, 2C and 2E) (Table 3). Here, PRNP is linked to Creutzfeldt Jacob disease.