Thus, the aim of this study was to investigate the impact of exercise and housing conditions on: a) Nr3c1 expression in the hippocampus, in particular Nr3c1-1F, b) Nr3c1 epigenetic regulation (miR-124 expression and DNA methylation at the promoter region of Nr3c1-1F), c) anxiety and d) adrenal gland weight and Mc2r expression. This evidence concerns the gene MC2R and Anxiety.