Interestingly, 2-DG prevented tumor-induced augmentation of CD4+CD25+ T-reg cells in tumor bearing mice (Fig 7C; 4.07% ± 0.41%; p < 0.001 and 4.89% ± 0.55%; p < 0.01 in 0.2% and 0.4% 2-DG group respectively compared to 7.74 ± 0.95 in control). Here, CD4 is linked to neoplasm.