Many cancers that overexpress cyclooxygenase-2 (COX-2) have been shown to have high intratumoral levels of PGE2, which has been shown to upregulate the invasive potential of pancreatic cancer cells through an ERK/Ets-1-dependent induction of MMP-2 expression and activity15. Here, ETS1 is linked to familial pancreatic carcinoma.