In our previous studies, we found that cantharidin presented cytotoxicity against pancreatic cancer cells through the NF-κB pathway that mediates apoptosis induction4, the c-Jun N-terminal kinase (JNK) pathway that inhibits cell growth3, 5, and the Wnt/β-catenin pathway that inhibits cell migration6. Here, NFKB1 is linked to familial pancreatic carcinoma.