MAPK8 and cancer: Taken together, our recent and present investigations have explored the mechanisms involved in the anti-cancer effect of cantharidin, including NF-κB pathway mediated apoptosis induction4, JNK pathway-dependent growth inhibition3, 5, Wnt/β-catenin pathway mediated inhibition on migration6, and multiple pathway-involved degradation of MMP2, leading to repressed invasive behaviour.