IL-8, as well as IL-6, can activate the Mitogen-activated protein kinase (MAPK) pathway, leading to production of vascular endothelial growth factor (VEGF) and neuropilin-224, 25, both of which have been correlated with angiogenesis and metastatic behaviour of pancreatic cancer cells24, 25, 26. This evidence concerns the gene WNK2 and pancreatic neoplasm.