In agreement with the results obtained from EBV-negative NPC cell lines (see Fig. 5b), downregulation of endogenous BART1 increased E-cadherin expression but decreased the expression of N-cadherin and vimentin in HONE1-EBV cells compared with the in-NC control (see Fig. 7c). This evidence concerns the gene CDH1 and nasopharyngeal carcinoma.