The FcRγ-Syk interaction is manifold stronger than the Zeta—ZAP-70 bond thus leading to a stronger downstream intracellular signal as evidenced by the increased tyrosine phosphorylation of signaling intermediates and increased calcium flux which contributes to the hyperexcitable phenotype of the SLE T cell [9]. The gene discussed is ZAP70; the disease is systemic lupus erythematosus.