A rewiring of the TCR in SLE T cells involves replacement of CD3ζ chain by the homologous Fc epsilon receptor I gamma (FcRγ) signaling chain [7] which recruits the spleen tyrosine kinase (Syk) instead of the zeta associated protein of 70kD (ZAP-70) normally recruited by the ζ chain [8]. This evidence concerns the gene CD247 and systemic lupus erythematosus.