Moreover, later symptoms of streptozotocin neuropathy, some of which are similarly insulin reversible, have been well documented and consist of hypoalgesia, large sensory nerve fibre pathology comprising demyelination, degeneration and Schwann cell damage and regeneration (Calcutt et al. 2004; Muller et al. 2008; Shaikh and Somani 2011; Vasconcelos et al. 2011; Weiss et al. 1995). The gene discussed is INS; the disease is neuropathy.