It was showed in in vitro models [12, 14, 15], and our results demonstrating that the upregulation of ALCAM in primary tumor and decreased expression of ALCAM in melanoma cells from nodal metastatic foci as the bad diagnostic indicators is the first report of this kind and is based on the analysis of well-documented clinical material and confirm experimental considerations conducted during studies in cell lines and using laboratory animals [12, 15]. Here, ALCAM is linked to melanoma.