ALCAM is instrumental for the formation of a triple complex on the surface of melanoma cells MT1-MMP/TIMP-2/pro-MMP-2 and the subsequent conversion of inactive form of metalloproteinase 2 (pro-MMP-2) into an active form responsible for the degradation of extracellular matrix and contributes to the formation of nodal and distant metastases [17]. This evidence concerns the gene ALCAM and melanoma.