ALCAM and neoplasm: In our study in cancer cells from the primary tumor we observed ALCAM expression in membranous-cytoplasmic and cytoplasmic location, dominantly in cell nests forming specific cytoaggregates, while in cancer cells from nodal metastatic foci the only pattern of intracellular distribution was cytoplasmic expression, which is in line with the considerations of the structural-functional ALCAM analysis (two-stage model of ALCAM expression).