MET and hepatocellular carcinoma: Although β-catenin alone is not sufficient to induce HCC in mice, hydrodynamic transfection of MET and activated β-catenin together (HDT-Met/β-Cat) induces multi-focal HCC in mice[42], resulting in innumerable (greater than 100) coalescing tumors that replace the majority of the hepatic parenchyma (Fig 6D, top panels, and S9A–S9B Fig top panels).