LEF1 and hepatocellular carcinoma: As expected, several known Wnt/β-catenin target genes showed increased expression in Tg(fabp10a:pt-β-cat) zebrafish livers with HCC compared to non-transgenic control sibling livers, including myca[26] (1.9-fold increase), lef1[27] (3.3-fold increase), pparda[28] (2.0-fold increase), and sp5[29] (2.1-fold increase).