It has been well demonstrated that let-7, miR-193-3p, and miR-195 were down-regulated in GH-secreting pituitary adenomas that accompanied excessive GH secretion[42, 43] and our previous study demonstrated that over-expression of ssc-let-7c in porcine pituitary cells leads to a decrease in GH secretion[44]. The gene discussed is GH1; the disease is pituitary gland adenoma.