However, we observed a significant increase of BM plasma IL-4 level in ND patients (median, 10.83 pg/ml; range 7.11–14.55 pg/ml) compared with the level in controls (median, 5.10 pg/ml; range, 1.99–8.20 pg/ml; *P = 0.0384). The gene discussed is IL4; the disease is Norrie disease.